QuizWise 74

Q. 1: Sjogren syndrome primarily affects which tissue?

A) Cornea
B) Retina
C) Exocrine glands
D) Uvea

Answer: C) Exocrine glands

Sjogren syndrome primarily affects the salivary and lacrimal glands which are exocrine glands

Carsons SE, Patel BC. Sjogren Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK431049/

Question 2: Most specific test for diagnosing Sjogren syndrome:

A) Salivary gland biopsy
B) Schirmer
C) PCR
D) All of the above

Answer: A) Salivary gland biopsy

Salivary gland biopsy is the most specific test for diagnosing Sjogren syndrome

Nguyen CQ, Peck AB. Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease. The ocular surface. 2009 Jan 1;7(1):11-27. https://doi.org/10.1016/S1542-0124(12)70289-6

Question 3: Not included in the ACR-EULAR classification criteria for primary Sjogren syndrome:

A) Ocular surface staining > 5 in atleast one eye
B) Anti-SSA/Anti-Ro positive
C) Raised RA factor
D) Schirmer’s test < 5 mm/5 min in at least one eye

Answer: C) Raised RA Factor

The most recent and new American College of Rheumatology/European League Against Rheumatism (ACR-EULAR) classification criteria for primary Sjögren syndrome includes focal lymphocytic sialadenitis, anti SSA/anti Ro positive, Ocular staining score > 5 in at least one eye, Schirmer’s test < 5 mm/5 min in at least one eye and unstimulated whole saliva flow rate < 0.1 ml/min. Rheumatoid factor is raised in secondary Sjogren syndrome.

Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K. Current concepts on Sjögren’s syndrome–classification criteria and biomarkers. European journal of oral sciences. 2018 Oct;126:37-48. https://doi.org/10.1111/eos.12536

Question 4: Secondary Sjogren syndrome is associated with which disease:

A) Rheumatoid arthritis
B) Systemic sclerosis
C) Systemic lupus erythematosus
D) All of the above

Answer: D) All of the above

Secondary Sjogren syndrome is  most commmonly associated with Rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus

Sebastian A, Szachowicz A, Wiland P. Classification criteria for secondary Sjögren’s syndrome. Current state of knowledge. Reumatologia. 2019;57(5):277-280 https://doi.org/10.5114/reum.2019.89520

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