GlaucomaLearn 4 (Left eye)

Vinay Nangia, Ravi Daberao


A female 50 year of age, came for a follow up for glaucoma. Her best corrected visual acuity was 6/6 in right eye and 6/6 in left eye. Anterior segment examination was normal. Right eye intraocular pressure was 16 mmHg and left eye was 17 mmHg. She was on brimonidine tartrate (0.2%) and timolol maleate (0.50 %) combination eyedrops since 2 years. Gonioscopy showed open angles in both eyes. Her axial length in right eye was 21.89 mm and left eye 21.93 mm. Her central corneal thickness in right eye was 458 microns and left eye was 478 microns.

Figure 1A: Left eye color fundus photograph showed vertical cup disc ratio of 0.90, inferior rim thinning. Inferior and superior wedge-shaped defects of RNFL (yellow arrows) were also noted. Beta zone parapapillary atrophy was seen inferiorly (red arrow).

Figure 1B: Left eye color fundus photograph with a magnified view of the disc and RNFL.  

Figure 2: Left eye OCT showed marked thinning of retinal nerve fiber layer in temperosuperior and temperoinferior quadrants (white arrow) ( Fig. 2b) and (black arrows) (Fig. 2d). Nasal superior  RNFL thinning also seen (Fig. 2b, yellow arrow) and (Fig. 2d, red arrow).  Notice the area of loss of RNFL of time, indicative of progressive damage (Fig 2d blue arrow).
Figure 3: Left eye posterior pole deviation map showed marked thinning of ganglion cell layer thickness (yellow arrows) (Fig.3A and B). GCL segmental measurements in the macula, (Fig 3D) showing thinning of supero-temporal, infero-temporal, inferior, nasal inferior sectors  < 1  percentile and superior sector < 5th percentile of healthy reference population.
Figure 4: Right eye Hood’s report showed reduction in retinal nerve fiber cell layer thickness at temporal, temperoinferior quadrants (Fig.4 A white arrow) and (Fig.4 B black arrow). There is a significant reduction of superior and inferior RNFL as shown by the heat map (Fig.4 D black arrows) and the field view (Fig.4 F white arrows). There is also a significant reduction of macular GCL shown by the heat map (Fig.8 E red arrow) and the field view (Fig.4 G yellow arrow).

Impression: The patient presented to us with advanced glaucomatous damage in the left eye with significant retinal nerve fiber layer and ganglion cell layer thinning in the left eye. The intraocular pressure in the left eye was 17 mmHg with two anti-glaucoma medications. The CCT in the left eye was 478 microns which is relatively less than the normative values found in Central India. The patient was advised to use prostaglandins in addition to the current medications.  It is important to note that over the last visit, there has been a loss in the superotemporal segment  and  superonasal segments.  Loss may not be detectable in the inferotemporal  segment, since there already exists significant damage leading to a flooring defect.  In view of the significant and progressive glaucomatous damage, the option of surgery for glaucoma was also discussed with the patient.

PS. For the effect of central corneal thickness in the management of such a patient please read about GlacuomaLearn  of the right eye.


Dr. Vinay Nangia
Suraj Eye Institute
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