- Which of the following is an absolute contraindication for SLET?
- Blind eye with no visual potential
- Dry keratinised ocular surface
- Partial limbal stem cell deficiency
- Both 1 and 2
2. Which of the following statements regarding SLET is false?
- Limbal stem cell deficiency in the donor eye is rare
- It cannot be repeated from the same donor eye
- It requires expensive stem cell laboratories
- Both 2 and 3
Answer 1 – 4. Both 1 and 2
The following attributes in the affected eye should be considered as absolute contraindications for SLET: dry ocular surface with a low schirmer score (< 10 mm) and / or ocular surface keratinisation, blind eye with no visual potential, disorganised anterior segment (adherent leucoma, extensive anterior synechiae) or uncorrected adnexal pathologies (trichiasis, entropion).
Reference – Shanbhag SS, Patel CN, Goyal R, Donthineni PR, Singh V, Basu S. Simple limbal epithelial transplantation (SLET): Review of indications, surgical technique, mechanism, outcomes, limitations, and impact. Indian J Ophthalmol 2019;67:1265-77
Answer 2 – 4. Both 2 and 3.
SLET can be repeated from the same donor eye since the harvested tissue is less than 1-2 clock hours, and it does not require a stem cell laboratory.
Reference – Sangwan VS, Basu S, MacNeil S, Balasubramanian D. Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency. Br J Ophthalmol. 2012 Jul;96(7):931-4