Spark QuizWise – 26

  1. Which of the following is an absolute contraindication for SLET?
  2. Blind eye with no visual potential
  3. Dry keratinised ocular surface
  4. Partial limbal stem cell deficiency
  5. Both 1 and 2

2. Which of the following statements regarding SLET is false?

  1. Limbal stem cell deficiency in the donor eye is rare
  2. It cannot be repeated from the same donor eye
  3. It requires expensive stem cell laboratories
  4. Both 2 and 3

QuizWise responses

Answer 1 – 4. Both 1 and 2

The following attributes in the affected eye should be considered as absolute contraindications for SLET: dry ocular surface with a low schirmer score (< 10 mm) and / or ocular surface keratinisation, blind eye with no visual potential, disorganised anterior segment (adherent leucoma, extensive anterior synechiae) or uncorrected adnexal pathologies (trichiasis, entropion).

Reference – Shanbhag SS, Patel CN, Goyal R, Donthineni PR, Singh V, Basu S. Simple limbal     epithelial transplantation (SLET): Review of indications, surgical technique, mechanism, outcomes, limitations, and impact. Indian J Ophthalmol 2019;67:1265-77

Answer 2 – 4. Both 2 and 3. 

SLET can be repeated from the same donor eye since the harvested tissue is less than 1-2 clock  hours, and it does not require a stem cell laboratory.

Reference – Sangwan VS, Basu S, MacNeil S, Balasubramanian D. Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency. Br J Ophthalmol. 2012 Jul;96(7):931-4

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